Epigenetics in Rare Diseases
نویسندگان
چکیده
منابع مشابه
Epigenetics in Rare Diseases
By definition, a rare disease is any condition that affects a small percentage of the population. However, the cutoff number for which a disease is considered as rare varies with different regions. In the United States, the cutoff was fewer than 200,000 people [1] and while in Japan, it was fewer than 50,000 [2]. For Europe, rare diseases are life-threatening or chronically debilitating ones in...
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Epigenetics pertains to heritable alterations in gene expression that do not involve modification of the underlying genomic DNA sequence. Historically, the study of epigenetic mechanisms has focused on DNA methylation and histone modifications, but the concept of epigenetics has been more recently extended to include microRNAs as well. Epigenetic patterning is modified by environmental exposure...
متن کاملEpigenetics in rheumatic diseases
With enormous speed novel data are emerging about regulating the expression of the genetically encoded information [1]. This highly complex regulatory network called epigenetics includes acetylation, methylation, phosphorylation, sumoylation and non-coding RNAs (ncRNA), such as miRNA and lncRNAs. Our laboratory is addressing over the past decade inflammatory rheumatic diseases [2], like rheumat...
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For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior plasticity, memory, cancer, autoimmune disease, and addiction as well as neurod...
متن کاملEpigenetics in inflammatory rheumatic diseases.
Inflammatory rheumatic disorders, such as rheumatoid arthritis (RA) and connective tissue diseases, are characterized by chronic inflammation that generally can be overcome by lifelong administration of immunosuppressive therapies. In most of these diseases, factors of genetic predisposition have been described, in particular the influence of distinct HLA haplotypes. In addition, environmental ...
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ژورنال
عنوان ژورنال: Journal of Rare Disorders: Diagnosis & Therapy
سال: 2018
ISSN: 2380-7245
DOI: 10.21767/2380-7245.100060